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Rixtuximab superior to azathioprine in autoimmune vasculitis
1. Rituximab was more effective at maintenance of remission at 28 months as compared to azathioprine for patients with antineutrophil cytoplasm antibody (ANCA)-positive vasculitides. 2. There were no...
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Key mutations may protect against coronary artery disease
1. Genetic mutations that led to the inactivation NPC1L1, a lipid transporter protein, were linked to lower low-density lipoprotein (LDL) and total cholesterol levels. Evidence Rating Level: 2 (Good)...
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Factor XI anti-sense oligonucleotide bests enoxaprin for venous...
1. A factor XI anti-sense oligonucleotide, FXI-ASO, was associated with lower incidence of venous thromboembolism compared with enoxaparin in patients undergoing elective total knee arthroplasty. 2....
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Device that increases coronary sinus pressure aids refractory chest pain
1. For patients with refractory chest pain (angina) and who are not candidates for revascularization, a new device that increases coronary sinus pressure provides significant symptomatic benefit....
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Bariatric surgery before pregnancy linked to lower risk of gestational diabetes
1. Bariatric surgery in obese patients before pregnancy was associated with a lower incidence gestational diabetes, large-for-gestational infants, and macrosomia. 2. The incidence of stillbirth and...
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Improved air quality linked to better lung function in children
1. A decrease in common air pollutants from fuel combustion was associated with an increase in lung function in children aged 11 to 15. Evidence Rating Level: 2 (Good) Study Rundown: For...
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Restrictive transfusion threshold non-superior to liberal threshold for...
1. For post-cardiac surgery patients, a restrictive transfusion threshold was not superior to a liberal transfusion threshold in terms of major infection and ischemic events at 3 months. 2. More deaths...
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Clindamycin and trimethoprim-sulfamethoxazole equally effective for...
1. Clindamycin or trimethoprim-sulfamethoxazole for 10-days was equally effective at achieving clinical cure of uncomplicated skin infections (cellulitis, abscess or both) at 7-10 days after completing...
View ArticleNo overall survival benefits to regional nodal irradiation for early-stage...
1. There was no significant 10 year survival benefit after axillary and medial supraclavicular nodal irradiation in patients with stages 1, 2 and 3 breast adenocarcinoma. 2. The study was initiated in...
View ArticleMild hypothermia for deceased organ donors reduces the rate of delayed graft...
1. The rate of delayed graft function in kidney transplant recipients is significantly reduced by hypothermia prior to implantation. 2. Kidney transplant recipients that benefit most from hypothermia...
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